Playdate is based on AmericanNorwegian author Dahl’s (no relation to Roald Dahl) fourth novel.　　In Playdate, a seemingly ordinary decision turns the world of Elisa, mum to two young kids, upside down. When Elisa’s nine-year-old daughter asks to go on an overnight playdate with her new best friend, Elisa agrees. But when she says goodnight to her daughter, she has no idea that she is about to be thrust into every parent’s worst nightmare, and when Elisa goes to pick her up, she discovers that the beautiful house was a holiday rental, while her daughter has disappeared. What follows is a manhunt across Europe, while Elisa and husband Fred find themselves the object of police scrutiny.

仁和医院高级精神科医生高立仁（方中信 饰）在婚礼前痛失为重案组探员的未婚妻莫敏儿（徐子珊 饰），随即陷入悲伤中不可自拔，甚至为此辞去工作。却不料就在此时，医院接收了一名声称被幻听所困更涉嫌强奸案的精神分裂患者。对此案不甚关心的高立仁路过案发现场，误打误撞帮助了博安医院法医精神科医生梁启荣（萧正楠 饰），并建立亦师亦友的关系。已经在外挂牌行医的连志森（蒋志光 饰）担心老友丧妻后萎靡不振的精神状态，多番劝说他重振旗鼓。高立仁也终于决定去博安医院任职。　　在随后一次同学聚会中，夜总会发生命案，高立仁意外结识了警方卧底林颂恩（杨怡 饰）。而在工作过程中，也逐渐与顾问医生卓慧翘（蒙嘉慧 饰）成为朋友。与此同时，连志森与梁启荣也分别陷入了暧昧不清的情爱关系……